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Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways
2025-12-05
psychiatry and clinical psychology
Title + abstract only
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BackgroundAnorexia Nervosa (AN) has a high mortality rate and often a chronic illness course, yet few existing treatments are effective. AN is heritable and shares genetic architecture with cardiometabolic traits, while the relationship to metabolomic markers is unknown. MethodsWe analyzed genome-wide association studies (GWAS) of 249 circulating plasma metabolomic biomarkers and AN to map their shared genetic architecture and compare with related mental health, anthropometric and cardiometabol...
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