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Liposomes Under Real Cell Conditions Behave Like Real Cells with a Single Pulsed Electric Field

Urabe, G.; Shimada, M.; Ogata, T.; Katsuki, S.

2019-12-01 biophysics
10.1101/860841 bioRxiv
Show abstract

Liposomes are widely assumed to present a straightforward physical model of cells. However, almost all previous liposome experiments with pulsed electric fields (PEFs) have been conducted in low-conductivity liquids, a condition that differs significantly from that of cells in medium. Here, we prepared liposomes consisting of soy bean lecithin and cholesterol, at a molar ratio of 1:1, in higher-conductivity liquid that approximated the conditions of red blood cells in phosphate-buffered saline, with inner and outer liquid conductivities of 0.6 and 1.6 S/m, respectively. We found that a single 1.1 kV/cm, 400 s PEF promoted cell-like spontaneous division of liposomes.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.