Statistical approach for ...a test chemical is considered to be positive... in regulatory toxicology: Trend and pairwise tests
Hothorn, L. A.
Show abstract
In regulatory toxicology an outcome is claimed positive when both a trend is significant and any pairwise test against control. Two statistical approaches are proposed: a joint Dunnett and Williams test (assuming the dose as a qualitative factor) and a joint test of the Tukey regression test and Dunnett test (assuming the dose as a quantitative covariate). Related R software is available.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- How important are concurrent vehicle control groups in (sub)chronic non-human primate toxicity studies conducted in pharmaceutical development? An opportunity to reduce animal numbers 95%
- In-Vivo and In-Vitro Toxicity Evaluation of 2,3-Dimethylquinoxaline: an Antimicrobial Found in a Traditional Herbal Medicine 94%
- An In-Silico Investigation of Menthol Metabolism 94%
Similar papers in this journal
- RAID: Regression Analysis based Inductive DNA microarray for Precise Read-Across 95%
- Primary Target Prediction of Bioactive Molecules from Chemical Structure 92%
- Pharmacokinetics of caffeine: A systematic analysis of reported data for application in metabolic phenotyping and liver function testing 91%
Similar papers in this journal
- Identifying Protein Features and Pathways Responsible for Toxicity using Machine learning, CANDO, and Tox21 datasets: Implications for Predictive Toxicology 93%
- Chemical composition, antimicrobial and antioxidant activities of essential oils from the receptacle of sunflower (Helianthus annuus L.) 91%
- Why Ortho- and Para-Hydroxy Metabolites Can Scavenge Free Radicals That the Parent Atorvastatin Cannot? Important Pharmacologic Insight from Quantum Chemistry 90%
Similar papers in this journal
- Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model 94%
- Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model 92%
- The combination of lipopolysaccharide and D-galactosamine administration show positive genotoxic effect in mice liver 92%
Similar papers in this journal
- Tat_BioV: Tattoo ink exposure and biokinetics of selected tracers in a short-term quasi-experimental clinical study of 24 subjects 91%
- High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics 90%
- Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.