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Statistical approach for ...a test chemical is considered to be positive... in regulatory toxicology: Trend and pairwise tests

Hothorn, L. A.

2019-11-29 pharmacology and toxicology
10.1101/858571 bioRxiv
Show abstract

In regulatory toxicology an outcome is claimed positive when both a trend is significant and any pairwise test against control. Two statistical approaches are proposed: a joint Dunnett and Williams test (assuming the dose as a qualitative factor) and a joint test of the Tukey regression test and Dunnett test (assuming the dose as a quantitative covariate). Related R software is available.

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