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Multiplexed biosensors for precision bacteria tropism in vivo

Chien, T.; Harimoto, T.; Kepecs, B.; Gray, K.; Coker, C.; Pu, K.; Azad, T.; Danino, T.

2019-11-21 synthetic biology
10.1101/851311 bioRxiv
Show abstract

The engineering of microbes spurs biotechnological innovations, but requires control mechanisms to confine growth within defined environments for translation. Here we engineer bacterial growth tropism to sense and grow in response to specified oxygen, pH, and lactate signatures. Coupling biosensors to drive essential gene expression reveals engineered bacterial localization within upper or lower gastrointestinal tract. Multiplexing biosensors in an AND logic-gate architecture reduced bacterial off-target colonization in vivo.

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The top 4 journals account for 50% of the predicted probability mass.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.