Redox signaling modulates Rho activity and tissue contractility in the C. elegans spermatheca
Kelley, C. A.; De Henau, S.; Bell, L.; Dansen, T. B.; Cram, E. J.
Show abstract
Actomyosin based contractility in smooth muscle and non-muscle cells is regulated by signaling through the small GTPase Rho and by calcium-activated pathways. We use the myoepithelial cells of the Caenorhabditis elegans spermatheca to study the mechanisms of coordinated myosin activation in vivo. Here, we demonstrate that redox signaling regulates RHO-1/Rho activity in this contractile tissue. Exogenous hydrogen peroxide treatment decreases spermathecal contractility by inhibiting RHO-1, which is mediated through a conserved cysteine in its active site (C20). Further, we identify a gradient of oxidation across the spermathecal tissue, which is regulated by the cytosolic superoxide dismutase, SOD-1. SOD-1 functions in the Rho pathway to inhibit RHO-1 through oxidation of C20. Our results suggest that SOD-1 functions to regulate the redox environment and to fine-tune Rho activity across the spermatheca.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during Drosophila oogenesis 96%
- The CCT chaperonin and actin modulate the ER and RNA-binding protein condensation during oogenesis to maintain translational repression of maternal mRNA and oocyte quality 95%
- Prostaglandins regulate invasive, collective border cell migration 94%
Similar papers in this journal
- Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in C. elegans 96%
- Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans 95%
- Differential modifications of the C-terminal tails of α-tubulin isoforms and their importance for kinesin-based microtubule transport in vivo 95%
Similar papers in this journal
- Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans 95%
- Nuclear translocation of tagged endogenous ERK/MPK-1 MAP Kinase denotes a subset of activation events in C. elegans development 94%
- Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans 94%
Similar papers in this journal
Similar papers in this journal
- Localized mRNA translation mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis 94%
- Drosophila SPG12 ortholog, reticulon-like 1, governs presynapticER organization and Ca2+ dynamics 94%
- Cell signaling facilitates apical constriction by basolaterally recruiting Arp2/3 via Rac and WAVE 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.