Disrupted serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
Stein, H.; Barbosa, J.; Rosa-Justicia, M.; Prades, L.; Morato, A.; Galan, A.; Arino, H.; Martinez-Hernandez, E.; Castro-Fornieles, J.; Dalmau, J.; Compte, A.
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We report markedly reduced working memory-related serial dependence with preserved memory accuracy in anti-NMDAR encephalitis and schizophrenia. We argue that NMDAR-related changes in cortical excitation, while quickly destabilizing persistent neural activity, cannot fully account for a reduction of memory-dependent biases. Rather, our modeling results support a disruption of a memory mechanism operating on a longer timescale, such as short-term potentiation.
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