The Pleiades cluster of fungal effector genes inhibit 1 host defenses
Navarrete, F.; Grujic, N.; Stirnberg, A.; Aleksza, D.; Gallei, M.; Adi, H.; Bindics, J.; Trujillo, M.; Djamei, A.
Show abstract
SummaryBiotrophic plant pathogens secrete effector proteins to manipulate the host physiology. Effectors suppress defenses and induce an environment favorable to disease development. Sequence-based prediction of effector function is difficulted by their rapid evolution rate. In the maize pathogen Ustilago maydis, effector-coding genes frequently organize in clusters. Here we describe the functional characterization of the pleiades, a cluster of ten symplastic effectors. Deletion of the pleiades leads to strongly impaired virulence and accumulation of reactive oxygen species (ROS) in infected tissue. Eight of the Pleiades suppress the production of ROS upon perception of pathogen associated molecular patterns (PAMPs). Although genetically redundant, the Pleiades target different host components. The paralogs Taygeta1 and Merope1 suppress ROS production in either the cytoplasm or nucleus, respectively. Merope1 targets and promotes the autoubiquitination activity of RFI2, a conserved family of E3 ligases that regulates the production of PAMP-triggered ROS burst and influences flowering time in plants.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Conditional gene expression reveals stage-specific functions of the unfolded protein response in the Ustilago maydis/maize pathosystem 97%
- Three LysM effectors of Zymoseptoria tritici collectively disarm chitin-triggered plant immunity 96%
- Structural and functional analysis of the cerato-platanin-like effector protein Cpl1 suggests diverging functions in smut fungi 96%
Similar papers in this journal
- The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity. 98%
- N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B 97%
- A Receptor Like Cytoplasmic Kinase evolved in Aeschynomene legumes to mediate Nod-independent rhizobial symbiosis 96%
Similar papers in this journal
- The Ralstonia solanacearum effector RipAV targets Plant U-box proteins and induces proteasomal-dependent degradation of BIK1 97%
- The Arabidopsis leucine-rich repeat receptor kinase MIK2 is a crucial component of pattern-triggered immunity responses to Fusarium fungi 96%
- The Arabidopsis WRR4A and WRR4B paralogous NLR proteins both confer recognition of multiple Albugo candida effectors 96%
Similar papers in this journal
- Effectors from a Bacterial Vector-Borne Pathogen Exhibit Diverse Subcellular Localization, Expression Profiles and Manipulation of Plant Defense 97%
- The Zymoseptoria tritici avirulence factor AvrStb6 accumulates in hyphae close to stomata and triggers a wheat defense response hindering fungal penetration 96%
- ER bodies are induced by Pseudomonas syringae and negatively regulate immunity 96%
Similar papers in this journal
- Acetylation of a fungal effector that translocates host PR1 facilitates virulence 96%
- Cell detoxification of secondary metabolites by P4-ATPase mediated vesicle transport 96%
- The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant specific motif and acts in a partially redundant manner with the tonoplast enzyme 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.