Caramel Dye IV Induces Oxidative Stress Damage In Liver And Kidney From Mice
Marins, E.; Silva, J. S. d.; Rosa, P. C.; Oliveira, V. A. d.; Pasinato, A. Z.; Moretto, J. G.; Vargas, J. E.; Soares, F. A. A.; Barcelos, R. P.
Show abstract
Caramel dye IV (C-IV) is a synthetic organic product, does not present nutritional, ergogenic, or technological factors, but leads to reactive oxygen species (ROS), causing damage to a wide range of molecules, leading to cancer, cardiovascular and neurodegenerative diseases development. We aimed to verify the effects of different doses of C-IV dye on the markers of oxidative stress in the liver and kidneys from male Swiss CF-1 mice, divided into 4 experimental groups: control; C-IV 0.3g/kg; C-IV 1g/kg and C-IV 3g/kg. We found that 3 g/Kg of C-IV dye promote oxidative damage in liver and kidney homogenates, evidenced by the increase of lipid peroxidation, reduction of free SH groups, and higher ROS production. As a consequence, increased superoxide dismutase and acetylcholinesterase enzymes activities were detected. These damages were confirmed through histology images. These results indicate that daily doses might induce oxidative stress damages and possible lead to chronic diseases development.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Combinatorial effects of Zingiber officinale and Citrus limon juices: Hypolipidemic and antioxidant insights from in vivo, in vitro, and in silico investigations 98%
- Cannabis sativa (Hemp) seed-derived peptides WVYY and PSLPA modulate the Nrf2 signaling pathway in human keratinocytes 97%
- Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells 96%
Similar papers in this journal
- The combination of lipopolysaccharide and D-galactosamine administration show positive genotoxic effect in mice liver 97%
- In vitro screening of anti-viral and virucidal effects against SARS-CoV-2 by Hypericum perforatum and Echinacea. 94%
- Effects of different environmental intervention durations on the intestinal mucosal barrier and the brain-gut axis in rats with colorectal cancer 94%
Similar papers in this journal
- A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase 96%
- Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation 96%
- Genoprotective effects of Chaga mushroom (Inonotus obliquus) polysaccharides in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes 95%
Similar papers in this journal
- The cytoprotective role of antioxidants in mammalian cells under rapidly varying temperature, pressure and UV conditions during stratospheric balloon campaign 93%
- Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19 93%
- Primary Target Prediction of Bioactive Molecules from Chemical Structure 93%
Similar papers in this journal
- Chemical composition, antimicrobial and antioxidant activities of essential oils from the receptacle of sunflower (Helianthus annuus L.) 96%
- Macrocybin, a mushroom natural triglyceride, reduces tumor growth in vitro and in vivo through caveolin-mediated interference with the actin cytoskeleton 93%
- Lignin isolated by microwave-assisted acid-catalyzed solvolysis induced cell death on mammalian tumor cells by modulating apoptotic pathways 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.