Back

Extensive functional repertoire underpins complex behaviours: insights from Parkinson's disease

Sorrentino, P.; Rucco, R.; Baselice, F.; De Micco, R.; Tessitore, A.; Hillebrand, A.; Mandolesi, L.; Breakspear, M.; Gollo, L. L.; Sorrentino, G.

2020-01-18 neuroscience
10.1101/823849 bioRxiv
Show abstract

Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics impair this adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinsons disease (PD). To test this hypothesis, we studied the functional repertoire - the number of distinct configurations of neural activity - using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in the abnormal patterns of brain activity. Our findings support the hypotheses that: symptoms in PD reflect impaired brain flexibility, this impairment preferentially involves the basal ganglia, and beta-band hypersynchronization is associated with reduced brain flexibility. These findings highlight the importance of extensive functional repertoires for behaviour and motor.

Matching journals

The top 8 journals account for 50% of the predicted probability mass.

1
NeuroImage
○ 903 papers in training set
Top 2%
9.4%
Similar papers in this journal
2
Brain
◐ 168 papers in training set
Top 0.4%
9.3%
Similar papers in this journal
3
npj Parkinson's Disease
○ 105 papers in training set
Top 0.4%
7.6%
Similar papers in this journal
4
NeuroImage: Clinical
○ 144 papers in training set
Top 0.4%
6.5%
Similar papers in this journal
5
Brain Communications
◐ 166 papers in training set
Top 0.6%
6.0%
Similar papers in this journal
6
Network Neuroscience
● 126 papers in training set
Top 0.3%
5.3%
7
Human Brain Mapping
○ 329 papers in training set
Top 1%
5.3%
8
eLife
● 5828 papers in training set
Top 24%
5.3%
50% of probability mass above
9
Neurobiology of Disease
○ 148 papers in training set
Top 0.9%
4.1%
10
Brain Topography
○ 29 papers in training set
Top 0.1%
4.1%
11
The Journal of Neuroscience
● 1025 papers in training set
Top 5%
3.9%
12
European Journal of Neuroscience
○ 189 papers in training set
Top 1%
3.1%
13
Progress in Neurobiology
○ 47 papers in training set
Top 0.1%
3.1%
14
Scientific Reports
○ 3612 papers in training set
Top 35%
3.1%
15
Communications Biology
○ 993 papers in training set
Top 10%
2.3%
16
Cortex
○ 119 papers in training set
Top 0.9%
2.3%
17
Frontiers in Neuroscience
○ 256 papers in training set
Top 3%
1.7%
18
Frontiers in Human Neuroscience
○ 77 papers in training set
Top 1%
1.7%
19
Imaging Neuroscience
● 282 papers in training set
Top 3%
1.7%
20
eneuro
● 439 papers in training set
Top 6%
1.1%
21
Cerebral Cortex
◐ 396 papers in training set
Top 4%
1.1%
22
Nature Communications
○ 5641 papers in training set
Top 52%
1.1%
23
Clinical Neurophysiology
○ 56 papers in training set
Top 0.7%
1.0%
24
Cell Reports
○ 1498 papers in training set
Top 30%
0.6%
25
Brain Structure and Function
○ 93 papers in training set
Top 2%
0.6%
26
Neuropsychologia
○ 85 papers in training set
Top 2%
0.6%
27
Experimental Neurology
○ 61 papers in training set
Top 2%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.