Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior
Flanigan, M.; Aleyasin, H.; Li, L.; Burnett, C. J.; Chan, K.; LeClair, K.; Lucas, E.; Matikainen-Ankney, B.; Janssen, W.; Takahashi, A.; Menard, C.; Pfau, M.; Golden, S.; Bouchard, S.; Calipari, E. S.; Nestler, E. J.; DiLeone, R.; Yamanaka, A.; Huntley, G.; Clem, R.; Russo, S.
Show abstract
Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have a wide variety of negative effects on patients, their families, and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, repeated domination of subordinate social targets is reinforcing. Here, we show that orexin neurons originating from the lateral hypothalamus activate a small population of GABAergic interneurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) to promote aggression and conditioned place preference (CPP) for aggression-paired contexts. Our study suggests that the orexin system is a potential target for the development of novel therapies aimed at reducing aggressive behaviors and provides the first functional evidence of a local inhibitory circuit within the LHb.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction 98%
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types 97%
- Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors 97%
Similar papers in this journal
Similar papers in this journal
- Monosynaptic inputs to ventral tegmental area glutamate and GABA co-transmitting neurons 97%
- Neurochemical signaling of reward and aversion by ventral tegmental area glutamate neurons 96%
- Rostral ventromedial medulla (RVM) projects to the lateral hypothalamic area (LHA) to drive aversion and anxiety 96%
Similar papers in this journal
- ACh signaling modulates activity of the GABAergic signaling network in the basolateral amygdala and behavior in stress-relevant paradigms. 97%
- Bidirectional emotional regulation through prefrontal innervation of the locus coeruleus 97%
- Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.