Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics
Hothorn, L. A.; Kluxen, F. M.; Hasler, M.
Show abstract
Sometimes a re-analysis of toxicological data is useful. However, this usually requires the availability of the original data and in many cases only summary data are available in the publications. Here the generation of pseudo-data under certain assumptions using extension packages in the open-source project R on statistical computing is shown. Several case studies are used to illustrate the applicability in regulatory toxicology.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- How important are concurrent vehicle control groups in (sub)chronic non-human primate toxicity studies conducted in pharmaceutical development? An opportunity to reduce animal numbers 95%
- Environmental monitoring and health assessment in an industrial town in central India: A cross-sectional study protocol 94%
- In-Vivo and In-Vitro Toxicity Evaluation of 2,3-Dimethylquinoxaline: an Antimicrobial Found in a Traditional Herbal Medicine 94%
Similar papers in this journal
- Comparative toxicogenomics of glyphosate and Roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in Sprague-Dawley rats 94%
- Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes: Involvement of Arene Oxide Intermediates 94%
- Ten Years of Using Key Characteristics of Human Carcinogens to Organize and Evaluate Mechanistic Evidence in IARC Monographs on the Identification of Carcinogenic Hazards to Humans: Patterns and Associations 93%
Similar papers in this journal
- Tat_BioV: Tattoo ink exposure and biokinetics of selected tracers in a short-term quasi-experimental clinical study of 24 subjects 93%
- Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis 90%
- High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics 90%
Similar papers in this journal
- Repeated exposure to chlorpyrifos is associated with a dose-dependent chronic neurobehavioral deficit in adult rats 92%
- Predicted Versus Observed Activity of PCB Mixtures Toward the Ryanodine Receptor 92%
- Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.