RecA influences biofilm development in the opportunistic pathogen Acinetobacter baumannii
Ching, C.; Downs, M.; Muller, P.; Isley, B.; Fowle, W.; Godoy, V. G.
Show abstract
Infections caused by Acinetobacter baumannii, a Gram-negative opportunistic pathogen, are difficult to eradicate due to the bacteriums propensity to quickly gain antibiotic resistances and form biofilms, a protective bacterial multicellular community. The A. baumannii DNA damage response (DDR) mediates the antibiotic resistance acquisition and regulates RecA in an atypical fashion; both RecALow and RecAHigh cell types are formed in response to DNA damage. The findings of this study demonstrate that the levels of RecA can influence the development, formation and dispersal, of biofilms through the global biofilm regulator bfmR. RecA loss results in surface attachment and prominent biofilms, while elevated RecA leads to diminished attachment and dispersal. These findings suggest that the challenge to treat A. baumannii infections may be explained by the induction of the DDR, common during infection, as well as the delicate balance between maintaining biofilms in low RecA cells, and promoting mutagenesis and dispersal in high RecA cells. This study underscores the importance of understanding the fundamental biology of bacteria to develop more effective treatments for infections.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- MogR is a ubiquitous transcriptional repressor affecting motility, biofilm formation and virulence in Bacillus thuringiensis 96%
- Manganese depletion leads to multisystem changes in the transcriptome of the opportunistic pathogen Streptococcus sanguinis 95%
- Spatial correlations and distribution of competence gene expression in biofilms of Streptococcus mutans 95%
Similar papers in this journal
- The Diguanylate Cyclase YfiN of Pseudomonas aeruginosa Regulates Biofilm Maintenance in Response to Peroxide 95%
- Interplay of Virulence Factors and Signaling Molecules: Albumin and Calcium-Mediated Biofilm Regulation in Bordetella bronchiseptica 95%
- Role of Tad Pili during the transition from Planktonic to Biofilm State in Bradyrhizobium diazoefficiens USDA 110 95%
Similar papers in this journal
Similar papers in this journal
- PQS-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa 94%
- Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling 94%
- Manganese uptake, mediated by SloABC and MntH, is essential for the fitness of Streptococcus mutans 93%
Similar papers in this journal
- Single-cell imaging reveals that Staphylococcus aureus is highly competitive against Pseudomonas aeruginosa on surfaces 93%
- The regulatory protein ChuP connects heme and siderophore-mediated iron acquisition systems required for Chromobacterium violaceum virulence 93%
- The global proteome of Streptococcus pneumoniae EF3030 under nutrient-defined in vitro conditions 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.