DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging
Hayano, M.; Yang, J.-H.; Bonkowski, M. S.; Amorim, J. A.; Ross, J. M.; Coppotelli, G.; Griffin, P. T.; Chew, Y. C.; Guo, W.; Yang, X.; Vera, D. L.; Salfati, E. L.; Das, A.; Thakur, S.; Kane, A. E.; Mitchell, S. J.; Mohri, Y.; Nishimura, E. K.; Schaevitz, L.; Garg, N.; Balta, A.-M.; Rego, M. A.; Gregory-Ksander, M.; Jakobs, T. C.; Zhong, L.; Wakimoto, H.; Mostoslavsky, R.; Wagers, A. J.; Tsubota, K.; Bonasera, S. J.; Palmeira, C. M.; Seidman, J. G.; Seidman, C. E.; Wolf, N. S.; Kreiling, J. A.; Sedivy, J. M.; Murphy, G. F.; Oberdoerffer, P.; Ksander, B. R.; Rajman, L. A.; Sinclair, D. A.
Show abstract
There are numerous hallmarks of aging in mammals, but no unifying cause has been identified. In budding yeast, aging is associated with a loss of epigenetic information that occurs in response to genome instability, particularly DNA double-strand breaks (DSBs). Mammals also undergo predictable epigenetic changes with age, including alterations to DNA methylation patterns that serve as epigenetic \"age\" clocks, but what drives these changes is not known. Using a transgenic mouse system called \"ICE\" (for inducible changes to the epigenome), we show that a tissues response to non-mutagenic DSBs reorganizes the epigenome and accelerates physiological, cognitive, and molecular changes normally seen in older mice, including advancement of the epigenetic clock. These findings implicate DSB-induced epigenetic drift as a conserved cause of aging from yeast to mammals.\n\nOne Sentence SummaryDNA breaks induce epigenomic changes that accelerate the aging clock in mammals
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons 97%
- Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline 96%
- Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility 96%
Similar papers in this journal
- Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment 97%
- Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice 96%
- Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging. 96%
Similar papers in this journal
- Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice 95%
- Mitochondrial Calcium Uptake Declines during Aging and is Directly Activated by Oleuropein to Boost Energy Metabolism and Skeletal Muscle Performance 95%
- Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.