Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples
Karimi Abadchi, J.; Nazari-Ahangarkolaee, M.; Gattas, S.; Bermudez-Contreras, E.; McNaughton, B. L.; Mohajerani, M. H.
Show abstract
A prevalent model is that sharp-wave ripples (SWR) arise spontaneously in CA3 and propagate recent memory traces outward to the neocortex to facilitate memory consolidation there. Using voltage and extracellular glutamate transient recording over widespread regions of mice dorsal neocortex in relation to CA1 multiunit activity (MUA) and SWR, we find that the largest SWR-related modulation occurs in retrosplenial cortex; however, contrary to the unidirectional hypothesis, neocortical activation exhibited a continuum of activation timings relative to SWRs, varying from leading to lagging. Thus, contrary to the model in which SWRs arise spontaneously in the hippocampus, neocortical activation often precedes SWRs and may thus constitute a trigger event in which neocortical information seeds associative reactivation of hippocampal indices. This timing continuum is consistent with a dynamics in which older, more consolidated memories may in fact initiate the hippocampal-neocortical dialog, whereas reactivation of newer memories may be initiated predominantly in the hippocampus.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Enhancement of hippocampal-thalamocortical temporal coordination during slow-frequency long-duration anterior thalamic spindles 97%
- Coordination of human hippocampal sharpwave-ripples during NREM sleep with cortical theta bursts, spindles, downstates and upstates 97%
- Cell assemblies in the cortico-hippocampal-reuniens network during slow oscillations 96%
Similar papers in this journal
- Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period 95%
- Spontaneous Variations in Arousal Modulate Subsequent Visual Processing and Local Field Potential Dynamics in the Ferret during Quiet Wakefulness 95%
- Developmental maturation of millimeter-scale functional networks across brain areas 95%
Similar papers in this journal
- Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla 96%
- Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex 96%
- Impaired Hippocampal-cortical interactions during sleep and memory reactivation without consolidation in a mouse model of Alzheimer’s disease 95%
Similar papers in this journal
- Modulation of hippocampal sharp-wave ripples by behavioral states and body movements in head-fixed rodents 97%
- Neuronal subtypes and connectivity of the adult mouse paralaminar amygdala 95%
- Hippocampal-prefrontal communication subspaces align with behavioral and network patterns in a spatial memory task 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.