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Nanoscale topography templates the organization of stable clathrin/AP-2 structures

Picas, L.; Carretero-Genevrier, A.; Sansen, T.; Rathar, R.; Sanchez-Fuentes, D.; Colom-Diego, A.; El Alaoui, F.; Viaud, J.; Gaudin, R.; Matile, S.; de Rossi, S.; Macchione, M.

2019-09-12 biophysics
10.1101/767590 bioRxiv
Show abstract

Membrane shape is a key feature of many cellular processes, including cell differentiation, division, migration, and trafficking. The development of nanostructured surfaces allowing for the in situ manipulation of membranes in living cells is crucial to understand these processes, but this requires complicated and limited-access technologies. Here, we investigate the self-organization of cellular membranes by using a customizable and bench top method allowing to engineer 1D SiO2 nanopillar arrays of defined sizes and shapes on high-performance glass compatible with advanced microscopies. As a result of this original combination, we provide a mapping of the morphology-induced modulation of the cell membrane mechanics, dynamics and steady-state organization of key protein complexes implicated in cellular trafficking and signal transduction.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.