Lineage-specific control of convergent cell identity by a Forkhead repressor
Mizeracka, K.; Rogers, J. M.; Shaham, S.; Bulyk, M. L.; Heiman, M. G.
Show abstract
During convergent differentiation, multiple developmental lineages produce a highly similar or identical cell type. However, few molecular players that drive convergent differentiation are known. Here, we show that the C. elegans Forkhead transcription factor UNC-130 is required in only one of three convergent lineages that produce the same glial cell type. UNC-130 acts transiently as a repressor in progenitors and newly-born terminal cells to allow the proper specification of cells related by lineage rather than by cell type or function. Specification defects correlate with UNC-130:DNA binding, and UNC-130 can be functionally replaced by its human homolog, the neural crest lineage determinant FoxD3. We propose that, in contrast to terminal selectors that activate cell-type specific transcriptional programs in terminally differentiating cells, UNC-130 acts early and specifically in one convergent lineage to produce a cell type that also arises from molecularly distinct progenitors in other lineages.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1 98%
- Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning 97%
- C. elegans LET-381/FoxF and DMD-4/DMRT control development of the mesodermal HMC endothelial cell 96%
Similar papers in this journal
- Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans 97%
- Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior 97%
- The enteric nervous system of C. elegans is specified by the Sine Oculis-like homeobox gene ceh-34 97%
Similar papers in this journal
- cAMP controls a trafficking mechanism that directs the neuron specificity and subcellular placement of electrical synapses 96%
- P granules protect RNA interference genes from silencing by piRNAs 96%
- Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut 95%
Similar papers in this journal
- β-importins Tnpo-SR and Cadmus and the small GTPase Ran promote ovarian cyst formation in Drosophila 96%
- A gene regulatory network for specification and morphogenesis of a Mauthner Cell homolog in non-vertebrate chordates 95%
- Interdependent regulation of stereotyped and stochastic photoreceptor fates in the fly eye 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.