Visualizing in vitro-in vivo correlation of miktoarm copolymer nanomicelles in cancer cellular uptake and trafficking
Cui, Z.; Zhang, X.; Zhang, X.; He, S.; Gao, W.; He, B.; Wang, X.; Zhang, H.; Zhong, Z.; Zhang, Q.
Show abstract
In this study, a clear correlation between the in vitro and in vivo cellular uptake and trafficking was discovered by delivering miktoarm copolymer nanomicelles (MCNs) to cancer cells and tumor tissues. To monitor this process, two different FRET pairs, DiO and DiI, DiD and DiR, were loaded into MCNs to monitor the Forster resonance energy transfer (FRET) efficiency. The change in FRET efficiency in vitro and in vivo demonstrated a similar sequence of events for the transport of MCNs: hyperbranched block PCL inserted into cytomembrane, while the loaded hydrophobic fluorescence probes were released and followed by time-dependent intracellular clustering within endocytic vesicles. Additionally, uptake of loaded fluorescence probes with successively increasing ratios of copolymers suggested that with the increase of mass ratio of copolymer to fluorescence probes, cellular uptake of probes significantly decreased. This result was also consistent with the uptake behavior in cancer tissues. Collectively, the interaction between MCNs and cellular membrane dictated the uptake and trafficking of core-loaded hydrophobic probes. This concept paves a new way to analyze in vitro-in vivo correlation of other nanocarriers for endocytosis mechanism studies as well as further novel copolymers design in biomedical applications.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Immunoengineered Nanobead System for the Isolation and Detection of Circulating Tumor Cells 95%
- Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells 94%
- Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomes 93%
Similar papers in this journal
- Hybrid Adipocyte-Derived Exosome Nano Platform for Potent Chemo-Phototherapy in Targeted Hepatocellular Carcinoma 96%
- Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking 95%
- Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment 95%
Similar papers in this journal
- Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy 95%
- Drug-dependent morphological transitions in spherical and worm-like polymeric micelles define stability and pharmacological performance of micellar drugs 94%
- Optical Nanosensors for Real-time Feedback on Insulin Secretion by β-Cells 94%
Similar papers in this journal
- Functionalization of lipid nanoemulsions with humanized antibodies using plug-and-play cholesterol anchor for targeting cancer cells 94%
- Single Pulse Heating of Nanoparticle Array for Biological Applications 91%
- Use of Nanosphere Self-Assembly to Pattern Nanoporous Membranes for the Study of Extracellular Vesicles 91%
Similar papers in this journal
- Enhancing Drug Delivery with Supramolecular Amphiphilic Macrocycle Nanoparticles: Selective Targeting of CDK4/6 Inhibitor Palbociclib to Melanoma 96%
- Rapid in situ forming PEG hydrogels for mucosal drug delivery 93%
- Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.