Major histocompatibility complex class I-restricted protection against murine cytomegalovirus requires missing-self recognition by the natural killer cell inhibitory Ly49 receptors
Parikh, B. A.; Bern, M. D.; Piersma, S. J.; Yang, L.; Beckman, D. L.; Poursine-Laurent, J.; Plougastel-Douglas, B.; Yokoyama, W. M. M.
Show abstract
Viruses have evolved strategies that highlight critical, intertwined host immune mechanisms. As postulated by the missing-self hypothesis, natural killer (NK) cells and major histocompatibility complex class I (MHC-I)-restricted cytotoxic T lymphocytes (CTLs) have opposing requirements for ubiquitously expressed MHC-I molecules. Since NK cell MHC-I-specific Ly49 inhibitory receptors prevent killing of cells with normal MHC-I, viruses evading CTLs by down-regulating MHC-I should be vulnerable to NK cells. However, definitive integrated in vivo evidence for this interplay has been lacking, in part due to receptor polymorphism and a proposed second function of Ly49 receptors in licensing NK cells via self-MHC-I. Here we generated mice lacking specific Ly49 inhibitory receptors to show their essential role in licensing and controlling murine cytomegalovirus (MCMV) infection in vivo in an MHC-restricted manner. When MCMV cannot down-regulate MHC-I, NK cells cannot control infection that instead is mediated by CTLs, as predicted by the missing-self hypothesis.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- {-}{-}{-}{-}{-}{-}{-}{-}RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence 96%
- Epstein-Barr virus protein EBNA-LP engages YY1 through leucine-rich motifs to promote naïve B cell transformation 95%
- The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness 95%
Similar papers in this journal
- Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection 96%
- The P681H mutation in the Spike glycoprotein escapes IFITM restriction and is necessary for type I interferon resistance in the SARS-CoV-2 alpha variant 95%
- HIV-1 Vif gained breadth in APOBEC3G specificity after cross-species transmission of its precursors 95%
Similar papers in this journal
- NK cell metabolic adaptation to infection promotes survival and viral clearance. 96%
- In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission 95%
- Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection 94%
Similar papers in this journal
- Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones. 95%
- HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection 93%
- Maternally transferred monoclonal antibodies protect neonatal mice from herpes simplex virus-induced mortality and morbidity 93%
Similar papers in this journal
- Optimal maturation of the SIV-specific CD8+ T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study 94%
- Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus 94%
- Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.