Non-junctional Cadherin3 regulates cell migration and contact inhibition of locomotion via domain-dependent opposing regulations of Rac1.
Ichikawa, T.; Stuckenholz, C.; Davidson, L. A.
Show abstract
Classical cadherins are well-known primary adhesion molecules responsible for physically connecting neighboring cells and signaling the cell-cell contact. Recent studies have suggested novel signaling roles for \"non-junctional\" cadherins (Niessen and Gottardi, 2008; Padmanabhan et al., 2017); however, the function of cadherin signaling independent of cell-cell contacts remains unknown. In this study, we used mesendoderm cells and tissues from gastrula stage Xenopus laevis embryos to demonstrate that extracellular and cytoplasmic cadherin domains regulate Rac1 in opposing directions in the absence of cell-cell contacts. Furthermore, we found that non-junctional cadherins regulate contact inhibition of locomotion (CIL) during gastrulation through alterations in the stability of the cytoskeleton. Live FRET imaging of Rac1 activity illustrated how non-junction cadherin3 (formerly C-cadherin) spatio-temporally regulates CIL. Our study provides novel insights into adhesion-independent signaling by cadherin3 and its role in regulating single and collective cell migration in vivo.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Global analysis of cell behavior and protein localization dynamics reveals region-specific functions for Shroom3 and N-cadherin during neural tube closure. 97%
- Notch controls the cell cycle to define leader versus follower identities during collective cell migration. 96%
- Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness 96%
Similar papers in this journal
- Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell Migration 97%
- Enhanced RhoA signaling stabilizes E-cadherin in migrating epithelial monolayers. 96%
- Interplay between cortical actin and E-cadherin dynamics regulates cell shape in the Drosophila embryonic epidermis 96%
Similar papers in this journal
- Cell-fate plasticity, adhesion and cell sorting complementarily establish a sharp midbrain-hindbrain boundary 96%
- Lmo7 recruits myosin II heavy chain to induce apical constriction in Xenopus ectoderm 96%
- Neural crest cells bulldoze through the microenvironment using Aquaporin-1 to stabilize filopodia 96%
Similar papers in this journal
Similar papers in this journal
- The mesodermal source of fibronectin is required for heart morphogenesis and cardiac outflow tract elongation by regulating cell shape, polarity, and mechanotransduction in the second heart field 96%
- Guidance by followers ensures long-range coordination of cell migration through α-Catenin mechanoperception 95%
- Dynamic remodelling of cadherin contacts in embryonic mesenchymal cells during differential cell migration 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.