Introns Control Intrinsic Noise
Sands, B.; Yun, S. R.; Mendenhall, A. R.
Show abstract
Introns are noncoding DNA elements found in between coding exons of most genes in most metazoans. Introns are known to both increase expression levels and provide means for making different protein products from the same gene via alternative splicing. It is thought that evolution has selected for these functions of introns. Here we present evidence for an additional reason why so many metazoan genes have introns, and why some do not. We found that introns control stochasticity in metazoan gene expression. They do this by controlling stochastic autosomal allele bias. We determined this by measuring the expression of differently colored reporter alleles with and without introns. We find that introns control stochastic autosomal allele biases using a 5-position dependent mechanism. Intron control of allele expression noise provides an additional mechanism to consider when pondering why so many metazoan genes have introns and why some have lost them.
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