Neutrophils Suppress Mucosal-Associated Invariant T Cells
Schneider, M.; Hannaway, R. F.; Lamichhane, R.; de la Harpe, S. M.; Tyndall, J. D.; Vernall, A. J.; Kettle, T.; Ussher, J. E.
Show abstract
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes that are abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial and fungal pathogens. Neutrophils, which are recruited early to sites of infection, play a non-redundant role in pathogen clearance and are crucial for controlling infection. The interaction of these two cell types is poorly studied. Here, we investigated both the effect of neutrophils on MAIT cell activation and the effect of activated MAIT cells on neutrophils. We show that neutrophils suppress the activation of MAIT cells by a cell-contact and H2O2 dependent mechanism. Moreover, highly activated MAIT cells were able to produce high levels of TNF that induced neutrophil death. We therefore provide evidence for a negative regulatory feedback mechanism in which neutrophils prevent over-activation of MAIT cells and, in turn, MAIT cells limit neutrophil survival.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Panton-Valentine leukocidin-induced neutrophil extracellular traps lack antimicrobial activity and are readily induced in patients with recurrent PVL+-Staphylococcus aureus infections 94%
- Differential glycosylation of alpha-1-acid glycoprotein (AGP-1) contributes to its functional diversity. 93%
- Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex 93%
Similar papers in this journal
- Ultra-pure isolation of low density neutrophils casts doubt on their exceptionality in health and disease 95%
- Neutrophils encompass a regulatory subset suppressing T cells in apparently healthy cattle and mice 95%
- Lasting alterations in monocyte and dendritic cell subsets in individuals after hospitalization for COVID-19 94%
Similar papers in this journal
- The role of VISTA engagement in limiting neutrophil-mediated inflammation 94%
- Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype 94%
- FcγRIIIb-deficient neutrophils have defects in ROS production, phagocytosis and actin polymerization following stimulation through FcγRs 93%
Similar papers in this journal
Similar papers in this journal
- Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory Plasticity 95%
- Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation 93%
- PROS1 released by human lung basal cells upon SARS-CoV-2 infection facilitates epithelial cell repair and limits inflammation. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.