Tonic GABAA conductance favors temporal over rate coding in the rat hippocampus
Dembitskaya, Y.; Wu, Y.-W.; Semyanov, A.
Show abstract
Synaptic plasticity is triggered by different patterns of neuronal network activity. Network activity leads to an increase in ambient GABA concentration and tonic activation of GABAA receptors. How tonic GABAA conductance affects synaptic plasticity during temporal and rate-based coding is poorly understood. Here, we show that tonic GABAA conductance differently affects long-term potentiation (LTP) induced by different stimulation patterns. The LTP based on a temporal spike - EPSP order (spike-timing-dependent [st] LTP) was not affected by exogenous GABA application. Backpropagating action potential, which enables Ca2+ entry through N-methyl-D-aspartate receptors (NMDARs) during stLTP induction, was only slightly reduced by the tonic conductance. In contrast, GABA application impeded LTP dependent on spiking rate (theta-burst-induced [tb] LTP) by reducing the EPSP bust response and, hence, NMDAR-mediated Ca2+ entry during tbLTP induction. Our results may explain the changes in different forms of memory under physiological and pathological conditions that affect tonic GABAA conductance.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Spatio-temporal dynamics of lateral Na+ diffusion in apical dendrites of mouse CA1 pyramidal neurons 96%
- Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons 96%
- Metaplastic reinforcement of long-term potentiation in rat hippocampal area CA2 by cholinergic receptor activation 96%
Similar papers in this journal
- Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses 96%
- Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex 95%
- Analogue signaling of somato-dendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons 95%
Similar papers in this journal
- Local Glutamate-Mediated Dendritic Plateau Potentials Change the State of the Cortical Pyramidal Neuron 97%
- Tumor necrosis factor-α modulates GABAergic and Dopaminergic neurons in the ventral periaqueductal gray of female mice. 94%
- Glutamatergic Control Of A Pattern-Generating Central Nucleus In A Gymnotiform Fish 94%
Similar papers in this journal
Similar papers in this journal
- Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity 97%
- Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach 95%
- α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.