Role of the imprinted allele of the p57Kip2 gene in mouse neocortical development
Imaizumi, Y.; Furutachi, S.; Watanabe, T.; Miya, H.; Kawaguchi, D.; Gotoh, Y.
Show abstract
Imprinted genes are expressed from only one allele in a parent of origin-specific manner. The cyclin-dependent kinase inhibitor p57Kip2 (p57) is encoded by an imprinted gene, with the paternal allele being silenced. The possible expression and function of the paternal allele of p57 have remained little studied, however. We now show that the paternal allele of the p57 gene is expressed at a low level in the developing mouse neocortex. Surprisingly, the central nervous system-specific conditional deletion of the paternal allele (pat cKO) at the p57 locus resulted in a marked reduction in brain size. Furthermore, pat cKO gradually reduced the number of neural stem-progenitor cells (NPCs) during neocortical development, and thus reduced the number of upper-layer neurons, which were derived from late-stage NPCs. Our results thus show that the paternal allele of the p57 locus plays a key role in maintenance of NPCs during neocortical development.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG 96%
- The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome 96%
- Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly 96%
Similar papers in this journal
- Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome 96%
- Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping 96%
- Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival 96%
Similar papers in this journal
- Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation. 97%
- Enhanced FGFR3 activity in post-mitotic principal neurons during brain development results in cortical dysplasia and axon miswiring 96%
- Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice 96%
Similar papers in this journal
- Dynamic regulation and requirement for ribosomal RNA transcription duringmammalian development 96%
- Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice 95%
- Single cell transcriptomic analysis revealed long-lasting adverse effects of prenatal tamoxifen administration on neurogenesis in prenatal and adult brains 95%
Similar papers in this journal
- The BMP antagonist Gremlin1 contributes to the development of cortical excitatory neurons, motor balance and fear responses 97%
- Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing 95%
- Retrovirus-derived acquired genes, RTL5 and RTL6, are novel constituents of the innate immune system in the eutherian brain. 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.