A mathematical model of mitochondrial calcium-phosphate dissolution as a mechanism for persistent post-CSD vasoconstriction
Xu, S.; Chang, J. C.; Chow, C. C.; Huang, H.
Show abstract
Cortical spreading depolarization (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. Most of the existing literature investigates the dynamics of short term phenomena such as the depolarization and repolarization of membrane potentials or large ion shifts. Here, we focus on the clinically-relevant hour-long state of neurovascular malfunction in the wake of CSDs. This dysfunctional state involves widespread vasoconstriction and a general disruption of neurovascular coupling. We demonstrate, using a mathematical model, that dissolution of calcium that has aggregated within the mitochondria of vascular smooth muscle cells can drive an hour-long disruption. We determine the rate of calcium clearance as well as the dynamical implications on overall blood flow. Based on reaction stoichiometry, we quantify a possible impact of calcium phosphate dissolution on the maintenance of F0F1-ATP synthase activity.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mix & Match: Phenotypic coexistence as a key facilitator of solid tumour invasion 95%
- Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework 95%
- Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm 95%
Similar papers in this journal
Similar papers in this journal
- Spatial redistribution of neurosecretory vesicles upon stimulation accelerates their directed transport to the plasma membrane 95%
- A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells 95%
- A biophysical minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.