DUX4 regulates oocyte to embryo transition in human
Vuoristo, S.; Hyden-Granskog, C.; Yoshihara, M.; Gawriyski, L.; Damdimopoulos, A.; Bhagat, S.; Hashimoto, K.; Krjutskov, K.; Ezer, S.; Paluoja, P.; Lundin, K.; Paloviita, P.; Recher, G.; Ranga, V.; Airenne, T.; Tamirat, M.; Jouhilahti, E.-M.; Otonkoski, T.; Tapanainen, J. S.; Kawaji, H.; Murakawa, Y.; Bürglin, T. R.; Varjosalo, M.; Johnson, M. S.; Tuuri, T.; Katayama, S.; Kere, J.
Show abstract
During the human oocyte-to-embryo transition, the fertilized oocyte undergoes final maturation and the embryo genome is gradually activated during the first three cell divisions. How this transition is coordinated in humans is largely unknown. We show that the double homeodomain transcription factor DUX4 contributes to this transition. DUX4 knockdown in human zygotes caused insufficient transcriptome reprogramming as observed three days after fertilization. Induced DUX4 expression in human embryonic stem cells activated transcription of thousands of newly identified bi-directional transcripts, including putative enhancers for embryonic genome activation genes such as LEUTX. DUX4 protein interacted with transcriptional modifiers that are known to couple enhancers and promoters. Taken together, our results reveal that DUX4 is a pioneer regulating oocyte-to-embryo transition in human through activation of intergenic genome, especially enhancers, and hence setting the stage for early human embryo development.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types 97%
- An ancient satellite repeat controls gene expression and embryonic development in Aedes aegypti through a highly conserved piRNA 97%
- A human-specific enhancer fine-tunes radial glia potency and corticogenesis 97%
Similar papers in this journal
- Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions 98%
- Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish 97%
- Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells 97%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.