Reconstructing the invasion route of DNA transposons using extant population samples
Weilguny, L.; Vlachos, C.; Selvaraju, D.; Kofler, R.
Show abstract
Reconstructing invasion routes of transposable elements (TEs), so far, required capturing an ongoing invasion with population samples from different geographic regions and time points. Here, we propose a more accessible approach. Abundantly occurring internal deletions of DNA transposons allow to trace the direction as well as the path of an invasion, even hundreds of generations after the spread of a TE. We validated this hypothesis with computer simulations and by accurately reproducing the route of the P-element invasion in Drosophila melanogaster. Finally, we used our method to shed light on the controversial hobo invasion in D. melanogaster. Our approach solely requires sequenced samples from extant populations and sequences of TEs of interest. Hence, DNA transposons in a wide range of model and non-model organisms may be analyzed. Our approach will further our understanding of TE dynamics, migration patterns, and the ecology of species.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Demographically explicit scans for barriers to gene flow using gIMble 95%
- Disentangling the determinants of transposable elements dynamics in vertebrate genomes using empirical evidences and simulations 94%
- Gene drive designs for efficient and localisable population suppression using Y-linked editors 93%
Similar papers in this journal
- Performance and limitations of linkage-disequilibrium-based methods for inferring the genomic landscape of recombination and detecting hotspots: a simulation study 92%
- Introgression between highly divergent sea squirt genomes: an adaptive breakthrough? 92%
- Phenotypic stasis with genetic divergence 92%
Similar papers in this journal
- piRNA clusters need a minimum size to control transposable element invasions 95%
- Evolutionary Consequences of Unusually Large Pericentric TE-rich Regions in the Genome of a Neotropical Fig Wasp 94%
- Within-population genome size variation is mediated by multiple genomic elements that segregate independently during meiosis 94%
Similar papers in this journal
- GenomeDelta: detecting recent transposable element invasions without repeat library 95%
- Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals 93%
- Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.