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JMJD6 Cleaves MePCE to Release P-TEFb

Zhang, G.; Lee, S.; Liu, H.; Hill, R.; Hong, X.; Liu, X.; Crawford, F.; Zhang, Q.; Kingsley, M.; Chen, Z.; Lengeling, A.; Bernet, K.; Marrack, P.; Kappler, J.; Hansen, K.; Zhou, Q.; Li, C.-Y.

2019-08-05 biochemistry
10.1101/725853 bioRxiv
Show abstract

More than 30% of genes in higher eukaryotes are regulated by promoter-proximal pausing of RNA polymerase II (Pol II). Phosphorylation of Pol II-CTD by positive transcription elongation factor (P-TEFb) is a necessary precursor event that enables productive transcription elongation. The exact mechanism on how the sequestered P-TEFb is released from the 7SK snRNP complex and recruited to Pol II-CTD remains unknown. In this report, we reveal methylphosphate capping enzyme (MePCE), a core component of the 7SK snRNP complex, as the cognate substrate for Jumonji domain-containing 6 (JMJD6)s novel proteolytic function. Our evidences consist of a crystal structure of JMJD6 bound to methyl-arginine, enzymatic assays of JMJD6 cleaving MePCE in vivo and in vitro, binding assays, and downstream effects of Jmjd6 knockout and overexpression on Pol II-CTD phosphorylation. We propose that JMJD6 assists bromodomain containing 4 (BRD4) to recruit P-TEFb to Pol II-CTD by disrupting the 7SK snRNP complex.

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