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Persistent Elevation of Electrical Pain Threshold following Continuous Theta Burst Stimulation over Primary Somatosensory Cortex in Humans

Rao, N.; Chen, Y.-T.; Ramirez, R.; Tran, J.; Li, S.; Parikh, P. J.

2019-08-06 neuroscience
10.1101/724344 bioRxiv
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BackgroundPrimary somatosensory cortex (S1) is involved in pain processing and thus its suppression using neuromodulatory techniques such as continuous theta burst stimulation (cTBS) might be a potential pain management strategy in patients with neuropathic pain. S1 cTBS is known to elevate pain threshold in young adults. However, the persistence of this effect is unknown.\n\nObjective/HypothesisWe hypothesized persistent elevation of pain threshold following cTBS over S1 in healthy, young adults.\n\nMethodsWe recruited ten subjects in a sham-controlled crossover design and recorded their electrical pain threshold (EPT) for 40 min following cTBS over S1. We assessed corticospinal excitability (CSE) to rule out the involvement of primary motor cortex due to spread of current.\n\nResultscTBS over S1 elevated EPT without modulating CSE compared to sham stimulation. EPT was elevated for 40 min post-cTBS.\n\nConclusionsS1 can be focally targeted using cTBS for a longer lasting pain relief in patients.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.