S-Acylation of plant immune receptors mediates immune signaling in plasma membrane nanodomains
Chen, D.; Ahsan, N.; Thelen, J.; Stacey, G.
Show abstract
S-Acylation is a reversible protein post-translational modification mediated by Protein S-acyltransferases (PATs). Here, we demonstrate that three plant immune receptors P2K1 (DORN1), FLS2 and CERK1, representing three distinct families of receptor like-kinases, are S-acylated by Arabidopsis PAT5 and PAT9 on the plasma membrane (PM). Mutations in Atpat5 and Atpat9 resulted in an elevated plant immune response, increased phosphorylation and decreased degradation of FLS2, P2K1 and CERK1 during immune signaling. Mutation of key cysteine residues S-acylated in these receptors resulted in a similar phenotype as exhibited by Atpat5/Atpat9 mutant plants. The data indicate that S-acylation also controls localization of the receptors in distinct PM nanodomains and, thereby, controls the formation of specific protein-protein interactions. Our study reveals that S-acylation plays a critical role in mediating spatiotemporal dynamics of plant receptors within PM nanodomains, suggesting a key role for this modification in regulating the ability of plants in respond to external stimuli.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity 97%
- Regulation of immune receptor kinases plasma membrane nanoscale landscape by a plant peptide hormone and its receptors 95%
- Acetylation of a fungal effector that translocates host PR1 facilitates virulence 95%
Similar papers in this journal
- Wounding and insect feeding trigger two independent MAPK pathways with distinct regulation and kinetics 95%
- Synaptotagmins Maintain Diacylglycerol Homeostasis at Endoplasmic Reticulum-Plasma Membrane Contact Sites during Abiotic Stress 95%
- Constitutive activation of leucine-rich repeat receptor kinase signaling pathways by BAK1-interacting receptor-like kinase 3 chimera 95%
Similar papers in this journal
- Direct acetylation of the conserved threonine of an immune regulator by bacterial effectors activates RPM1-dependent immunity in Arabidopsis 95%
- A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease 95%
- Brassinosteroid recruits FERONIA to safeguard cell expansion in Arabidopsis 94%
Similar papers in this journal
- Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast 94%
- A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis 94%
- Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity 94%
Similar papers in this journal
- Type one protein phosphatases (TOPPs) catalyze EIN2 dephosphorylation to regulate ethylene signaling in Arabidopsis 95%
- Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products 95%
- Aphid effectors suppress plant immunity via recruiting defence proteins to processing bodies 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.