Cdc24, the source of active Cdc42, transiently interacts with septins to create a positive feedback between septin assembly and bud site formation in yeast cells.
Chollet, J.; Dünkler, A.; Bäuerle, A.; Vivero-Pol, L.; Gronemeyer, T.; Johnsson, N.
Show abstract
Yeast cells select at the beginning of each cell cycle the position of their new bud. The recruitment of the septins to this prospective bud site (PBS) is one of the critical events in a complex assembly pathway that culminates in the outgrowth of a new daughter cell. The septin-rods follow hereby the high concentration of Cdc42GTP that is generated by the focused location of its GEF Cdc24. We show that Cdc24 not only activates Cdc42 but temporarily interacts shortly before budding with Cdc11, the subunit that caps septin rods at its both ends. Mutations in Cdc24 that reduce the affinity to Cdc11 impair septin assembly and decrease the stability of the polarity patch. The interaction between septins and Cdc24 thus reinforces bud assembly at sites where septin structures are formed. Once the septins polymerize into the ring, Cdc24 transfers to its center and directs from there the further outgrowth of the membrane.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A short linear motif, conserved from yeast to human, binds to members of the Spa2/GIT1 family of cortical scaffold proteins 98%
- Cdc42 couples septin recruitment to the axial landmark assembly via Axl2 in budding yeast 98%
- The Hob proteins are novel and conserved lipid binding proteins at ER-PM contact site 97%
Similar papers in this journal
Similar papers in this journal
- Differentially accessible Cdc4 phospho-degrons regulate Ctf19CCAN kinetochore subunit stability in mitosis 98%
- Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing in S. cerevisiae 97%
- Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress 97%
Similar papers in this journal
Similar papers in this journal
- The Spc105-Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of the Ipl1/Aurora B kinase 97%
- Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis 96%
- Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.