Role and impact of the gut microbiota in a Drosophila model for parkinsonism
Feltzin, V.; Wan, K. H.; Celniker, S. E.; Bonini, N. M. M.
Show abstract
Drosophila is poised to be a powerful model organism for studies of the gut-brain axis due to the relative simplicity of its microbiota, similarity to mammals, and efficient methods to rear germ-free flies. We examined the gut-brain axis in Drosophila models of autosomal recessive parkinsonism and discovered a relationship between the gut microbiota and parkin loss of function. The number of live bacteria was increased approximately five-fold in the gut of aged parkin null animals. Conditional RNAi showed that parkin is required in gut enterocytes and not in neurons or muscle to maintain microbial load homeostasis. To examine the significance of gut microbiota, we reared germ-free parkin flies and discovered that removal of microbes in the gut improves the animals resistance to paraquat. Sequencing of 16S rDNA revealed microbial species with altered relative abundance in parkin null flies compared to controls. These data reveal a role for parkin activity in maintaining microbial composition and abundance in the gut, suggesting a relationship between parkin function and the gut microbiota, and deepening our understanding of parkin and the impacts upon loss of parkin function.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity 96%
- Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae 96%
- Muscle function and homeostasis require macrophage-derived cytokine inhibition of AKT activity in Drosophila 96%
Similar papers in this journal
- Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila 95%
- Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration 93%
- Dissecting neuron-specific functions of circadian genes using modified cell-specific CRISPR approaches 93%
Similar papers in this journal
- Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow 96%
- Replication competition drives the selective mtDNA inheritance in Drosophila ovary 94%
- Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in Drosophila melanogaster 93%
Similar papers in this journal
- Metabolic cooperation among commensal bacteria supports Drosophila juvenile growth under nutritional stress 94%
- Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling 94%
- SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.