Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses
Park, J. H.; Cornick, S.; Nigro, G.; Bertin, G.; Dejardin, F.; Smits, R.; Berard, M.; Langa Vives, F.; Gomperts Boneca, I.; Gewirtz, A.; Chassaing, B.; Barnich, N.; Sansonetti, P.; Eberl, G.
Show abstract
Microbe-associated molecular patterns (MAMPs) are recognized by pattern recognition receptors (PRRs) of the innate immune system. Flagellin, the primary component of bacterial flagella, is recognized by membrane TLR5 and cytoplasmic NLRC4 receptors, which promote a vigorous pro-inflammatory response typically associated with bacterial infection. However, herein, we report that the nature of the flagellin-induced response is highly dependent on the physiological state of the tissue. Specifically, in the steady state, epithelial cell detection of flagellin orchestrates an anti-inflammatory response mediated by IL-33-dependent type 2 regulatory T cells while, in the context of injury, it induces a pro-inflammatory response mediated by myeloid cells, IL-18 and Th17 cells. Likewise, in the absence of infection, bacterial symbionts expressing high levels of flagellin induce a type 2 response. These data demonstrate that, depending on the inflammatory state of the milieu, MAMPs can function both as immunogens or tolerogens.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape 97%
- TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin 95%
- An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module 95%
Similar papers in this journal
Similar papers in this journal
- A20's Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis 97%
- Distinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis 96%
- Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.