Pericyte Bridges in Homeostasis and Hyperglycemia: Reconsidering Pericyte Dropout and Microvascular Structures
Corliss, B. A.; Ray, H. C.; Doty, R.; Mathews, C.; Sheybani, N.; Fitzgerald, K.; Prince, R.; Kelly-Goss, M.; Murfee, W. L.; Chappell, J.; Owens, G.; Yates, P. A.; Peirce, S. M.
Show abstract
Diabetic retinopathy threatens the vision of a third of diabetic patients. Progression of the disease is attributed to the dropout of pericytes, a cell type that enwraps and stabilizes the microvasculature. In tandem with this presumptive pericyte dropout, there is enriched formation of structures assumed to be remnants of collapsed or regressed vessels, previously classified as acellular capillaries, string vessels, and basement membrane bridges. Instead of endothelial cells, we show that pericytes colocalize with basement membrane bridges, and both bridging structures are enriched by cell-specific knockout of KLF4 and reversibly enriched with elevation of Ang-2, PDGF-BB, and blood sugar. Our data suggests that pericyte counts from retinal digests have misclassified pericyte bridges as endothelial structures and have exaggerated the role of pericyte loss in DR progression. In vivo imaging of corneal limbal vessels demonstrates pericyte migration off-vessel, implicating pericyte movement in formation of pericyte bridges and pathogenesis of diabetic retinopathy.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy 97%
- Corticosteroids prevent pathological angiogenesis yet compromise reparative vascular remodeling in the retina 96%
- Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels 96%
Similar papers in this journal
- Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control 95%
- Prdm16 amplifies Notch signaling and suppresses venous lineage specification to prevent arteriovenous malformations during vascular development 94%
- Reconstituted high-density lipoproteins rescue diabetes-impaired endothelial cell metabolic reprograming and angiogenic responses to hypoxia 94%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.