Multiple Measures Reveal The Value of Both Race And Geographic Ancestry For Self-Identification
Damotte, V.; Zhao, C.; Lin, C.; Williams, E.; Louzoun, Y.; Madbouly, A.; Kotlarz, R.; McDaniel, M.; Norman, P. J.; Lizee, A.; Myres, N. M.; Ball, C. A.; Chahine, K. G.; Byrnes, J.; Wang, Y.; Maiers, M.; Hollenbach, J. A.
Show abstract
There is long-standing tension regarding whether and how to use race or geographic ancestry in biomedical research. We examined multiple self-reported measures of race and ancestry from a cohort of over 100,000 U.S. residents alongside genetic data. We found that these measures are often non-overlapping, and that no single self-reported measure alone provides a better fit to genetic ancestry than a combination including both race and geographic ancestry. We also found that patterns of reporting for race and ancestry appear to be influenced by participation in direct-to-consumer genetic ancestry testing. Our results demonstrate that there is a place for the language of both race and geographic ancestry as we seek to empower individuals to fully describe their family history in research and medicine.\n\nOne Sentence SummarySelf-identification in the United States according to both racial and geographic terms best reflects genetic ancestry in individuals.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A hypothetical intervention to reduce inequities in anxiety for Multiracial people: simulating an intervention on childhood adversity 91%
- Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design 90%
- Social inequalities in COVID-19 deaths by area-level income: patterns over time and the mediating role of vaccination in a population of 11.2 million people in Ontario, Canada 90%
Similar papers in this journal
- Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study 92%
- Imputed Gene Expression Risk Scores: A Functionally Informed Component of Polygenic Risk 90%
- Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples 90%
Similar papers in this journal
- Population histories of the United States revealed through fine-scale migration and haplotype analysis 91%
- Declining autozygosity over time: an exploration in over 1 million individuals from three diverse cohorts 91%
- Population Structure and Migration in the Eastern Highlands of Papua New Guinea; a Region Impacted by the kuru Epidemic 91%
Similar papers in this journal
Similar papers in this journal
- Evaluation of imputation performance of multiple reference panels in a Pakistani population 91%
- A stop-gain variant in BTNL9 is associated with atherogenic lipid profiles 91%
- BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.