Enhancing rigor and reproducibility in maternal immune activation models: practical considerations and predicting resilience and susceptibility using baseline immune responsiveness before pregnancy
Estes, M. L.; Farrelly, K.; Cameron, S.; Aboubechara, J. P.; Haapanen, L.; Schauer, J. D.; Horta, A.; Prendergast, K.; MacMahon, J. A.; Shaffer, C. I.; Le, C. T.; Kincheloe, G. N.; Tan, D. J.; van der List, D.; Bauman, M. D.; Carter, C. S.; Van de Water, J.; McAllister, A. K.
Show abstract
Despite the potential of rodent models of maternal immune activation (MIA) to identify new biomarkers and therapeutic interventions for a range of psychiatric disorders, their value is currently limited by issues of scientific rigor and reproducibility. Here, we report three sources of variability--the immunogenicity of the poly(I:C), the baseline immune responsiveness (BIR) of the females prior to pregnancy, and differences in immune responses in C57/B6 dams across vendors. Similar to the variable effects of human maternal infection, MIA in mice does not cause disease-related phenotypes in all offspring and the magnitude and type of maternal response, determined by a combination of poly(I:C) dose and BIR, predicts offspring outcome. Together, our results provide recommendations for optimization of MIA protocols to enhance rigor and reproducibility and reveal new factors that drive susceptibility of some pregnancies and resilience of others to MIA-induced abnormalities in offspring.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor 98%
- The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control 95%
- Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age 94%
Similar papers in this journal
- miR-218 in adolescence predicts and mediates vulnerability to stress 95%
- Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice 93%
- p75 neurotrophin receptor in pre-adolescent prefrontal PV interneurons promotes cognitive flexibility in adult mice 93%
Similar papers in this journal
- MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function 94%
- The autism-associated loss of δ-catenin functions disrupts social behaviors 94%
- A Kalirin Missense Mutation Enhances Dendritic RhoA Signaling and Leads to Regression of Cortical Dendritic Arbors Across Development 93%
Similar papers in this journal
- Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome 95%
- Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. 94%
- SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants 94%
Similar papers in this journal
- Perinatal IL-1-induced Inflammation Suppresses Tbr2+ Intermediate Progenitor Cell Proliferation in the Developing Hippocampus accompanied by Long-Term Behavioral Deficits 93%
- Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model. 93%
- FINCA disease mouse model exhibits altered behaviour and immune response 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.