Does human P-glycoprotein efflux involve transmembrane alpha helix breakage?
Bonito, C. A.; Ferreira, M. J. U.; Ferreira, R.; dos Santos, D. J.
Show abstract
The occluded conformation suggested in a recent article that revealed a new inward-facing conformation for the human P-glycoprotein may not represent the closing of a gate region but instead an artifact derived from lateral compression in a too small sized nanodisc, used to stabilize the transmembrane domains of the transporter.
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