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Linking transcriptome and chromatin accessibility in nanoliter droplets for single-cell sequencing

Chen, S.; Lake, B.; Zhang, K.

2019-07-04 genomics
10.1101/692608 bioRxiv
Show abstract

Linked profiling of transcriptome and chromatin accessibility from single cells can provide unprecedented insights into cellular status. Here we developed a droplet-based Single-Nucleus chromatin Accessibility and mRNA Expression sequencing (SNARE-seq) assay, that we used to profile neonatal and adult mouse cerebral cortices. To demonstrate the strength of single-cell dual-omics profiling, we reconstructed transcriptome and epigenetic landscapes of cell types, uncovered lineage-specific accessible sites, and connected dynamics of promoter accessibility with transcription during neurogenesis.

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