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Modeling the Role of Hypoxia in Glioblastoma Growth and Recurrence Patterns

Curtin, L.; Hawkins-Daarud, A.; Porter, A.; Owen, M. R.; van der Zee, K.; Swanson, K. R.

2019-07-05 cancer biology
10.1101/691238 bioRxiv
Show abstract

A typical feature of glioblastoma (GBM) growth is local recurrence after surgery. However, some GBMs recur distally. It has been noted that GBM patients with perioperative ischemia are more likely to have distal recurrence and that GBM cells migrate faster under hypoxic conditions. We apply the Proliferation Invasion Hypoxia Necrosis Angiogenesis (PIHNA) model to examine the effect of faster hypoxic cell migration on simulated GBM growth. Results suggest that a highly migratory hypoxic cell population drives the growth of the whole tumor and leads to distant recurrence, as do higher normoxic tumor cell migration and low cellular proliferation rates.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.