Localization of a feline autosomal dominant dwarfism locus: a novel model of chondrodysplasia
Lyons, L. A.; Fox, D. B.; Chesney, K. L.; Britt, L. G.; Buckley, R. M.; Coates, J. R.; Gandolfi, B.; Grahn, R. A.; Hamilton, M. J.; Middleton, J. R.; Sellers, S. T.; Villani, N. A.; 99 Lives Consortium,
Show abstract
Despite the contribution of a few major genes for disproportionate dwarfism in humans, many dwarf patients are yet genetically undiagnosed. In domestic cats, disproportionate dwarfism has led to the development of a defined breed, the Munchkin or Minuet. This study examined the genetic aspects of feline dwarfism to consider cats as a new biomedical model. DNA from dwarf cats was genetically analyzed using parentage, linkage, and genome-wide association studies as well as whole genome sequencing. Each genetic approach localized the dwarfism phenotype to a region on cat chromosome B1. No coding variants suspected as causal for the feline dwarfism were identified but a critical region of [~]5.7 Mb from B1:170,278,183-175,975,857 was defined, which implicates a novel gene controlling disproportionate dwarfism. A yet unidentified but novel gene variant, likely structural or regulatory, produces disproportionate dwarfism in cats, which may define undiagnosed human patients.
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