Cardiac contraction velocity has evolved to match heart rate with body size through variation in β-cardiac myosin sequence.
Johnson, C. A.; McGreig, J. E.; Vera, C. D.; Mulvihill, D. P.; Ridout, M.; LEINWAND, L. A.; Wass, M. N.; Geeves, M. A.
Show abstract
Heart rate and the maximum velocity of contraction of striated muscle are inversely related to species size. As mammals evolve to different sizes, adaptations are required such as slower contracting heart and skeletal muscles. Analysis of the motor domain of {beta}-myosin from 67 mammals from two clades identifies 14 sites, out of 800, strongly associated with body mass (p<0.01) but not with the clade (p>0.05). Nine of these sites were mutated in the human {beta}-myosin to make it resemble the rat sequence. Biochemical analysis revealed that the rat-human {beta}-myosin chimera functioned like the native rat myosin with a two fold increase in both motility and in the rate of ADP release from the actin.myosin cross-bridge (the step that limits contraction velocity). Both clades use the same small set of amino acids to adjust contraction velocity, suggesting a limited number of ways in which velocity can be manipulated.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and non-ischemic human hearts 93%
- Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions 93%
- Human hypertrophic cardiomyopathy mutation R712L suppresses the working stroke of cardiac myosin and can be rescued by omecamtiv mecarbil 92%
Similar papers in this journal
- The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 deafness 95%
- Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties 94%
- Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states 93%
Similar papers in this journal
- A new perspective on the evolution of the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors 94%
- Cancer associated talin point mutations disorganise cell adhesion and migration 92%
- Recurrent erosion of COA1/MITRAC15 demonstrates gene dispensability in oxidative phosphorylation 92%
Similar papers in this journal
Similar papers in this journal
- Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria 92%
- Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants 91%
- Reconstitution of cytolinker-mediated crosstalk between actin and vimentin 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.