Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis
Alvarez, M. J.; Yan, P.; Alpaugh, M. L.; Bowden, M.; Sicinska, E.; Zhou, C. W.; Karan, C.; Realubit, R. B.; Mundi, P. S.; Grunn, A.; Jäger, D.; Chabot, J. A.; Fojo, A. T.; Oberstein, P. E.; Hibshoosh, H.; Milsom, J. W.; Kulke, M. H.; Loda, M.; Chiosis, G.; Reidy-Lagunes, D. L.; Califano, A.
Show abstract
Quantitative metrics to objectively assess the fidelity of cancer models, such as cell lines, organoids, or patient-derived xenografts (PDXs), remain elusive, with histological criteria or the presence of specific mutations often used as driving principles. We show that molecular criteria, based on the regulatory proteins responsible for maintaining transcriptional cell state and its regulatory network, are effective in identifying models that can recapitulate drug mechanism of action and drug sensitivity, independent of histological consideration.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting 94%
- An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical models of colorectal cancer 93%
- MmCMS: Mouse models' Consensus Molecular Subtypes of colorectal cancer 92%
Similar papers in this journal
- Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies. 94%
- A dual readout embryonic zebrafish xenograft model of rhabdomyosarcoma to assess clinically relevant multi-receptor tyrosine kinase inhibitors 92%
- Platinum chemotherapy induces lymphangiogenesis in cancerous and healthy tissues that can be prevented with adjuvant anti-VEGFR3 therapy 92%
Similar papers in this journal
- Barcoded Competitive Clone-Initiating Cell (BC-CIC) Analysis Reveals Differences in Ovarian Cancer Cell Genotype and Niche Specific Clonal Fitness During Growth and Metastasis In Vivo 93%
- DNA replication during acute MEK inhibition drives acquisition of resistance through amplification of the BRAF oncogene 93%
- Oncogenic ERRB2 signals through the AP-1 transcription factor to control mesenchymal-like properties of oesophageal adenocarcinoma 92%
Similar papers in this journal
- Bcl-xL is a key mediator of apoptosis following KRASG12C inhibition in KRASG12C mutant colorectal cancer. 94%
- Ovarian cancers with low CIP2A tumor expression constitute an APR-246 sensitive disease subtype 94%
- Exploitation of sulfated glycosaminoglycan status for precision medicine of platinums in triple-negative breast cancer 93%
Similar papers in this journal
- A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer 93%
- Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts 93%
- Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanoma 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.