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EpiSort: Enumeration of cell types using targeted bisulfite sequencing

Aran, D.; Dover, R. S.; Lundy, K. E.; Leipold, M. D.; Xuhuai, J.; McDevitt, S. L.; Davis, M. M.; Butte, A. J.

2019-06-21 immunology
10.1101/677211 bioRxiv
Show abstract

The cellular composition of tumors is now recognized as an essential phenotype, with implications to diagnostic, progression and therapy efficacy. A tool for accurate profiling of the tumor microenvironment is lacking, as single-cell methods and computational approaches are not applicable or suffer from low accuracy. Here we present EpiSort, a novel strategy based on targeted bisulfite sequencing, which allows the accurate enumeration of 23 cell types and may be applicable to cancer studies.

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