Back

Impaired Desynchronization of Beta Activity Underlies Memory Deficits in People with Parkinson’s Disease

MacDonald, H.; Brittain, J.-S.; Spitzer, B.; Hanslmayr, S.; Jenkinson, N.

2019-06-12 neuroscience
10.1101/667550 bioRxiv
Show abstract

There is a pressing need to better understand the mechanisms underpinning the increasingly recognised non-motor deficits in Parkinsons disease. Brain activity during Parkinsons disease is excessively synchronized within the beta range (12-30Hz). However, relatively little is known about how the abnormal beta rhythms impact on non-motor symptoms. In healthy adults, beta desynchronization is necessary for successful episodic memory formation. We investigated whether there was a direct relationship between decreased beta modulation and memory formation in Parkinsons disease. Electroencephalography recordings were made during an established memory-encoding paradigm. Parkinsons participants showed impaired memory strength (P = 0.023) and reduced beta desynchronization (P = 0.014) relative to controls. Longer disease duration was correlated with a larger reduction in beta desynchronization, and a concomitant reduction in memory performance. These novel results extend the notion that pathological beta activity is causally implicated in the motor and (lesser appreciated) non-motor deficits inherent to Parkinsons disease.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
Neuropsychologia
○ 85 papers in training set
Top 0.1%
12.9%
Similar papers in this journal
2
Brain Communications
◐ 166 papers in training set
Top 0.3%
9.8%
Similar papers in this journal
3
Neurobiology of Aging
○ 107 papers in training set
Top 0.2%
7.3%
Similar papers in this journal
4
The Journal of Neuroscience
● 1025 papers in training set
Top 2%
7.3%
Similar papers in this journal
5
Cortex
○ 119 papers in training set
Top 0.2%
6.7%
Similar papers in this journal
6
Brain
◐ 168 papers in training set
Top 0.6%
6.2%
50% of probability mass above
7
European Journal of Neuroscience
○ 189 papers in training set
Top 0.4%
5.5%
8
Neuroscience
○ 97 papers in training set
Top 0.4%
2.6%
9
Scientific Reports
○ 3612 papers in training set
Top 38%
2.6%
10
Neurobiology of Disease
○ 148 papers in training set
Top 1%
2.4%
11
NeuroImage: Clinical
○ 144 papers in training set
Top 1%
2.4%
12
npj Parkinson's Disease
○ 105 papers in training set
Top 0.7%
2.4%
13
Frontiers in Human Neuroscience
○ 77 papers in training set
Top 0.7%
2.4%
14
Frontiers in Aging Neuroscience
○ 74 papers in training set
Top 0.7%
2.1%
15
Cerebral Cortex Communications
◐ 36 papers in training set
Top 0.1%
1.9%
16
Psychophysiology
○ 77 papers in training set
Top 0.6%
1.9%
17
Neurobiology of Learning and Memory
○ 40 papers in training set
Top 0.2%
1.7%
18
Schizophrenia Research
○ 35 papers in training set
Top 0.2%
1.5%
19
NeuroImage
○ 903 papers in training set
Top 5%
1.3%
20
eLife
● 5828 papers in training set
Top 59%
1.1%
21
Clinical Neurophysiology
○ 56 papers in training set
Top 0.6%
1.1%
22
Experimental Neurology
○ 61 papers in training set
Top 1%
1.0%
23
Progress in Neurobiology
○ 47 papers in training set
Top 0.7%
1.0%
24
PLOS ONE
● 5266 papers in training set
Top 59%
0.8%
25
Brain and Behavior
○ 43 papers in training set
Top 1%
0.8%
26
Nature Communications
○ 5641 papers in training set
Top 56%
0.8%
27
eneuro
● 439 papers in training set
Top 8%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.