PROTEINATOR: Web-UI exploring repurposing hypotheses of PROTEIN InhibiTORs based on protein interactions
Tangadu, S.; Shankar, S.; Varanasi, B. V.; Athri, P.
Show abstract
PROTEINATOR is the first version of a staggered, multi-paradigm and extensible drug repurposing platform, focusing on a novel data analytic and integration strategy to find repurposing candidates that have potential to modulate targets through protein-protein interactions. The UI was created as an explorer to find indirect drugs for a protein of interest. PROTEINATOR is developed as a web application that lets researchers search for alternate drugs for a protein of interest, based on the proteins direct interaction with a another druggable protein. This unique tool provides researchers exploring specific implicated protein(s) (in the context of drug development), alternate, plausible routes to modulation by listing proteins that interact with the protein of interest that have reported inhibitors. It is a search engine to identify indirect drugs through connecting various databases, thus avoiding multiple steps and avoiding any manual errors. Using a representative set of databases, 112083 number of indirect drug interactions are discovered that are potential modulators of proteins, detailed annotations of which are provided in the UI. PROTEINATOR is freely available at http://www.proteinator.in.
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