The role of the endoplasmic reticulum in in vivo cancer FDG kinetics
Scussolini, M.; cossu, v.; Marini, C.; Sambuceti, G.; Caviglia, G.; piana, m.
Show abstract
A very recent result obtained by means of an in vitro experiment with cancer cultured cells has configured the endoplasmic reticulum as the preferential site for the accumulation of 2-deoxy-2-[18F]fluoro-D-glucose (FDG). Such a result is coherent with cell biochemistry and is made more significant by the fact that reticular accumulation rate of FDG is dependent upon extracellular glucose availability. The objective of the present paper was to confirm this result in vivo, using small animal models of CT26 cancer tissues. Specifically, assuming that the endoplasmic reticulum plays a specific functional role in the framework of a three-compartment model for FDG kinetics, we are able to explain positron emission tomography dynamic data in a more reliable way than by means of a standard Sokoloff two-compartment system. This result is made more solid from a computational viewpoint by means of some identifiability considerations based on a mathematical analysis of the compartmental equations.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Estimating the SARS-CoV-2 infected population fraction and the infection-to-fatality ratio: A data-driven case study based on Swedish time series data 93%
- Radiation-induced cell cycle perturbations: acomputational tool validated with flow-cytometrydata 93%
- Nonlinear neural network dynamics accounts for human confidence in a sequence of perceptual decisions 92%
Similar papers in this journal
- An organ-based multi-level model for glucose homeostasis: organ distributions, timing, and impact of blood flow 93%
- Inferring Insulin Secretion Rate From Sparse Patient Glucose and Insulin Measures 91%
- Modeling the dynamics of Let-7-coupled gene regulatory networks linking cell proliferation to malignant transformation 90%
Similar papers in this journal
- Structural and practical identifiability of contrast transport models for DCE-MRI 96%
- Mechanistic model for human brain metabolism and the neurovascular coupling. 94%
- Combining Hypoxia-Activated Prodrugs and Radiotherapy in silico: Impact of Treatment Scheduling and the Intra-Tumoural Oxygen Landscape 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.