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Pre-existent adult sox10+ cardiomyocytes contribute to myocardial regeneration in the zebrafish

Sande-Melon, M.; Marques, I. J.; Galardi-Castilla, M.; Langa, X.; Perez-Lopez, M.; Botos, M.; Martinez-Guzman, G.; Ferreira-Francisco, D. M.; Pavlinic, D.; Benes, V.; Bruggmann, R.; Mercader, N.

2019-06-07 developmental biology
10.1101/662536 bioRxiv
Show abstract

During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from pre-existing ones. It is unclear whether the heart is comprised of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identified a subset of pre-existent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded massively after cryoinjury. Genetic ablation of sox10+ cardiomyocytes severely impaired cardiac regeneration revealing that they play a crucial role for heart regeneration.

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