Precision-targeted metabolomics method characterizes differential metabolomes in multiple-biological matrixes and cell-mitochondria
Luo, X.; Guo, R.; Liu, J.; Zhang, A.; Wang, X.; Lu, H.
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This new method has the capacity to dynamically analyse the metabolome of interest in diverse biological matrixes by offering coverage of rat urine, plasma, liver, brain, intestine, stomach, heart, spleen, lung, faeces, fresh plant tissues, cells and microbes. In addition, this new method enables specific and efficient analysis of microdontia metabolomes, non-microdontia and whole cell metabolomes, as well as can engage in absolute determination of 84 key clinical-wide metabolites in different biological matrixes, to enable the complementary support of clinical diagnosis and classification of diseases. To demonstrate the applicable capacity of this new method, multiple-matrixes differential metabolomes were firstly characterized using this new method to coordinate metabolic modifications underlie hepatitis induced by carbon tetrachloride (CCL4) in rats, such finding provides novel insight into the pathogenesis and therapeutics of hepatitis in clinic. Altogether, we are fully confident that this new metabolomics method will be widely welcomed by scientists in different niches to solve their key questions accordingly.
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