Bioorthogonal antigens allow the unbiased study of antigen processing and presentation
Araman, C.; Pieper-Pournara, L.; van Leeuwen, T.; Kampstra, A. S. B.; Bakkum, T.; Marqvorsen, M. H. S.; Nascimento, C.; van der Wulp, W.; Groenewold, M. G. J. M.; Camps, M. G. M.; Overkleeft, H. S.; Ossendorp, F.; Toes, R.; van Kasteren, S. I.
Show abstract
Proteolysis is fundamental to many biological processes. In the immune system, it underpins the activation of the adaptive immune response: degradation of antigenic material into short peptides and presentation thereof on major histocompatibility complexes, leads to activation of T-cells. This initiates the adaptive immune response against many pathogens.
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