Safety and immunogenicity of a quadrivalent meningococcal polysaccharide vaccine (MPV ACYW135) compared with a quadrivalent meningococcal conjugate vaccine (Menactra): a study protocol of a randomized non-inferiority trial in Mali
Viviani, S.; Hu, R.; Sow, S. O.; Tapia, M. D.; Haidara, F. C.; Diallo, F.; Traore, Y.; Traore, A.; Kodio, M.; Shi, L.
Show abstract
A phase IV clinical trial is designed to compare the safety and immunogenicity of a quadrivalent meningococcal polysaccharide vaccine (Walvax MPV ACYW135) compared with a quadrivalent meningococcal conjugate vaccine (Sanofi Pasteur Menactra(R)) in children aged 2-10 years in Mali, a country within the meningitis belt, to demonstrate the benefit that might be brought by vaccinations with meningococcal polysaccharide vaccines. Eligible subjects will be randomized at a 1:1 ratio to receive either Walvax MPV ACYW135 or Sanofi Pasteur Menactra(R). All subjects will be followed up for solicited/unsolicited adverse events and any serious adverse events. Immunogenicity will be determined with the level (titer) of functional antibodies by serum bactericidal assay using baby rabbit complement (rSBA) with non-inferiority demonstrated. Clinical Trial RegistrationNCT04450498
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Immunogenicity and Safety of a 14-valent pneumococcal polysaccharide conjugate vaccine (PNEUBEVAX 14TM) administered to 6-8 weeks old healthy Indian Infants: A single blind, randomized, active-controlled, Phase-III study 97%
- A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: safety, reactogenicity and immunogenicity 97%
- Safety, tolerability and immunogenicity of Biological E’s CORBEVAX™ vaccine in children and adolescents: A Prospective, Randomised, Double-blind, Placebo controlled, Phase-2/3 Study 97%
Similar papers in this journal
- Safety and effectiveness of dose-sparing strategies for seasonal influenza vaccine: a rapid scoping review of fractional dosing of the intramuscular influenza vaccine 95%
- Reports of myocarditis and pericarditis following mRNA COVID-19 vaccines: A systematic review of spontaneously reported data from the UK, Europe, and the US and of the literature 94%
- COVID-19 vaccines and evidence-based medicine 94%
Similar papers in this journal
- Immunogenicity and safety of Quadrivalent Influenza HA vaccine compared with Trivalent Influenza HA vaccine and evaluation of Quadrivalent Influenza HA vaccine batch-to-batch consistency in Indonesian children and adults 96%
- Immunogenicity and safety of a recombinant adenovirus type-5 COVID-19 vaccine in adults: data from a randomised, double-blind, placebo-controlled, single-dose, phase 3 trial in Russia 96%
- Covid-19 Vaccination in Pregnancy: A Systematic Review 95%
Similar papers in this journal
- Immunogenicity and Safety Following a Homologous Booster Dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): A Phase 2 Randomized Placebo-Controlled Trial 97%
- Immunogenicity and safety of a third dose, and immune persistence of CoronaVac vaccine in healthy adults aged 18-59 years: interim results from a double-blind, randomized, placebo-controlled phase 2 clinical trial 96%
- Safety of MVA-BN in Healthcare Personnel, Democratic Republic of the Congo 95%
Similar papers in this journal
- Safety and immunogenicity of the BBIBP-CorV vaccine in adolescents aged 12-17 years in Thai population, prospective cohort study 97%
- A First in Human Trial to Evaluate the Safety and Immunogenicity of a G Protein Based Recombinant Respiratory Syncytial Virus Vaccine in Healthy Adults 18-45 Years 96%
- Analysis of immunization, adverse events, and efficacy of a fourth dose of BNT162b2 vaccine 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.