Local B cell maturation and mast cell regulation of choroid plexus function in early life.
Ali-Moussa, S.; Blas-Medina, A.; Josephides, J.; Mirabeau, O.; Bouteau, I.; Matijevic, T.; Kovacs, M.; Pakulska, V.; Pangan, A. R.; Thomas, C.; Hasselblatt, M.; Dong, X.; Matondo, M.; Gaudenzio, N.; Jonsson, F.; Travier, L.; Deczkowska, A.
Show abstract
Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of cerebrospinal fluid and responds to stimuli from its local immune microenvironment. Here, using single-cell sequencing, we chart the establishment of the immune niche within the CP from birth to adulthood. We demonstrate that the CP is an active site for the development of B cells from early pro-B cells to mature B cells. We also characterize a transient population of CP mast cells that is highly abundant in the perinatal period. Single activation of these cells shortly after birth led to activation of serotonin-dependent secretion from the CP epithelial cells and resulted in cognitive impairment later in life. Our findings highlight the crucial nature of the CP as a neuroimmune interface, where cellular crosstalk regulates key functions of CP activity, thereby guiding brain development.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A dynamic gene regulatory code drives synaptic development of hippocampal granule cells 97%
- Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment 96%
- Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia 96%
Similar papers in this journal
- Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. 96%
- Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons 95%
- Seroconversion stages COVID19 into distinct pathophysiological states 95%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.